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From time to time on television, in newspapers and magazines and on the Internet there are messages about miracle drugs to help lose weight. Most of these drugs belong to the so-called dietary supplements (biologically active additives). And not all of them are safe and approved for use.

If we consider obesity a disease (and in fact it is), then appears the need for the drug for the treatment of this illness.

Official permission to use the drug to treat obesity is sibutramine. This substance is a part of more than a dozen popular medicines for weight loss, including the largest known is the German medicine Meridia. Many people know and domestic analogue of the drug - Goldline. Being much cheaper than their foreign "colleagues", Sibutramine doesn’t lose in efficiency.

Like many peers, Goldline affects the area of the brain responsible for hunger. Goldline creates the effect of satiety and at the table you eat much less than usual. Taking this drug, you once said that you do not want to "bite" at work, you spend more time on your immediate duties, rather than the traditional tea. At the same time you will not constantly chase hunger, familiar to those who have ever tried to diet. Taking Sibutramine you change your eating habits, and even after the medicine will remain faithful to them, and it will be easier to maintain the your ideal weight.

But that is not all. Goldline causes the body to increase energy consumption, driving metabolism, normalize blood glucose and cholesterol levels.

The mechanism of Sibutramine action 

Sibutramine is structurally similar to amphetamine class, although not possess their biological properties. Sibutramine a centrally acting drug is a serotonin reuptake inhibitor (53%), norepinephrine (54%) and dopamine (16%), resulting in increases in the levels of these neurotransmitters in inter-ischemic space. Increasing thus the concentration of serotonin in the center of hunger and satiety, medicine suppresses appetite. 


The main effects of sibutramine: inhibition of presynaptic reuptake monoaminergic neurotransmitter in the central nervous system and appetite suppression; activation of secretion of anorexigenic neuropeptides; an increase in energy consumption and activation of the sympathetic effects of the peripheral nervous system. Sibutramine may cause a change (improvement) of mood, because in the control of energy homeostasis and mood are often used overlapping areas of the brain (e.g., serotonergic). Sibutramine is approved by the FDA in 1997 as the effictive drug for weight loss. 


Contraindications: 

Mental illness 

Hypersensitivity 

Diseases of the heart and arteries 

Hypertonic disease 

Angle-closure glaucoma 

Prostatic hyperplasia 

Pregnancy, lactation and children's age 

Simultaneous reception of MAO inhibitors (antidepressants) 

As for side effects, these include increased heart rate, a slight increase in blood pressure, dry mouth, nausea, constipation, insomnia. These side effects are in most cases do not require discontinuation of the medicine, they are temporary and very rapidly.

Those who are waiting for a rapid and significant effect of the drug may be somewhat disappointed to attack any significant changes in the weight and volume of the body should be Goldline constantly and at least three months. It provides the optimal reduction of weight - about 0.5-1 kg per week. In addition, the greatest effect is achieved by addition of the drug with diet and moderate exercise - if you stick to Sibutramine while sitting in a chair all day - do not expect miracles!

Goldline is very convenient regimen - once a day, regardless of the meal. How to think about it - take! It is produced in suitable containers in the form of gelatin capsules, 10 mg or 15 mg. One package is recomended for one month.

If you are ready to run to the medicine store for this medicine, do not rush. Sibutramine, as has been said - this medicine, and any medication should be taken only on prescription. As a rule, Sibutramine appoint those who staged the second degree of obesity and higher. The pharmacy you can buy this drug only by prescription. Of course, if you search well, you can find a pharmacy where you sell the medicine without a prescription. But is it worth risking their own health?

After all Goldline have a big list of contraindications: hypertension, chronic liver and kidney failure, mental illness. In diseases of the heart before taking Goldline should consult a cardiologist. Often the problems with being overweight occur in women after childbirth. Remember that during pregnancy and lactation medications should be sharply limited. This applies to Goldline - risking the health of the children.

Choosing slimming, turn your attention to Goldline, but before consult your doctor.


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